11 Day American Cruise Lines River Cruise from Louisville to Knoxville 2027

Day 1 Huntsville, AL

Enjoy a 1-night stay in this dynamic city, home to NASA’s Marshall Space Flight Center and known for its deep ties to space exploration and technology. Often called “Rocket City,” explore its unique blend of scientific heritage and southern charm, with a vibrant arts, music, and food scene. Surrounded by the foothills of the Appalachian Mountains, Huntsville also provides easy access to hiking, nature trails, and scenic views.

Day 2 Cruising the Tennessee River

Step aboard and feel the blend of classic charm and contemporary comfort of our ship. Join us for a lively Welcome Reception, where you'll meet fellow travelers and enjoy a taste of Southern hospitality. We’ll toast to you, the crew and an unforgettable voyage along the Appalachians Mountains.

Day 3 Chattanooga, TN

Chattanooga, on the shores of the Tennessee River, boasts a stunning blend of natural beauty and urban charm, with the scenic backdrop of the Appalachian Mountains hugs its skyline. The city’s past comes alive at the historic Bluff View Art District, where cobblestone streets lead to galleries and cafes. Food enthusiasts will delight in the diverse culinary scene, from classic Southern comfort dishes to innovative farm-to-table fare. Visitors can explore vibrant neighborhoods filled with art galleries, boutiques, and museums, all reflecting the city’s unique heritage and culture.

Day 4 Cruising the Appalachian Mountains

Admire sweeping views of tree-covered ridges rising above calm, winding waterways as you enjoy a full day cruising along the magnificent Appalachian Mountains. From the sun deck, you can see layers of mountains stretching into the distance, often softened by drifting mist or touched with golden light. Throughout your day, read your favorite book in one of our comfortable lounges, gather with fellow guests in the restaurant and share your adventures, or listen to an engaging presentation by our onboard expert. As the sun sets, view magnificent mountains silhouetted against the glowing sky, bringing a tranquil close to an amazing day.

Day 4 Fort Southwest Point, TN

Experience this reconstructed 18th-century military outpost that once played a key role in early American expansion and Cherokee relations. Overlooking the confluence of the Clinch and Tennessee Rivers, Fort Southwest Point offers not only scenic views, but also insight into frontier life. Just a few miles away, the area later became significant for the role it played during World War II with the development of the Manhattan Project. This secret project helped develop the atomic bomb, transforming the region into a hub of scientific and military activity. During our stop in Fort Southwest Point, guests can explore both early American frontier history and its unexpected connection to one of the most pivotal events of the 20th century.

Day 6 Cruising Along the Great Smoky Mountains

Today is yours to bask in the beauty of a constantly changing landscape of forested hills, misty peaks, and rocky shorelines. From your private balcony, admire the glassy surface of mountain lakes that mirror the sky and the soft outline of ridgelines in the distance. Bald eagles and herons fly overhead, while deer and other wildlife occasionally appear along the wooded banks. As your ship winds through narrow channels and open water, the play of sunlight and shadow across the mountains creates a sense of perfect serenity.

Day 7 Knoxville, TN

Begin your land adventure in Knoxville, nestled in the foothills of the Great Smoky Mountains. Take time to explore this vibrant city, known for hosting the 1982 World’s Fair, and the Sunsphere—an iconic structure from the event—still stands as a city landmark. It is also home to the University of Tennessee, which brings energy, sports culture, and academic influence to the area. The city’s historic Market Square offers a mix of local shops, restaurants, and live entertainment. Knoxville played a key role in the Civil War and has a rich history reflected in its architecture and museums.

Day 8 Pigeon Forge, TN

Travel from Knoxville to Pigeon Forge, nestled in the scenic foothills of the Smokies. Upon your arrival, settle into your hotel. Pigeon Forge, known for its eccentric attractions, including whimsical museums like the Titanic Museum Attraction, shaped like the famous ship, and WonderWorks, an upside-down building filled with interactive exhibits. Be treated to a spectacular dinner show at Dolly Parton's Stampede, where skilled horseback riders and dazzling effects bring stories to life in an arena, all while enjoying a true Southern dinner and getting to know your Adventure Guides and fellow explorers.

Day 9 Great Smoky Mountain National Park

Journey through the trails of Cades Cove in a caravan of Jeeps, guided by narrators who will share the history behind each twist in the path. This venture proves the profound beauty and calming presence of this Appalachian retreat.

Continue your exploration at the Sugarlands Visitor Center, where you'll gather insights into the park's detailed history and its diverse ecological community. A short, easy walk from the Visitor Center brings you to Cataract Falls, where water ribbons down the mountainside.

Day 10 Great Smoky Mountain National Park / Gatlinburg, TN

The Great Smoky Mountains stretch across the horizon, their peaks shrouded in a misty veil that gives the range its name. The dense forests blanket rolling hills in shades of emerald and gold, interspersed with crystal-clear streams that move through the valleys.

Above the alpine tree line, Clingmans Dome offers one of the most captivating reaching views in the Appalachian Mountains. On your second day in the park, ascend to this man-made observation point for sweeping views of the Smoky Mountains and the landscape beyond.

Visit nearby Gatlinburg, Tennessee, a charming town hiding in a narrow valley just outside the park, that captures all the quirky charm you’ve come to know along the way.

Day 11 Knoxville, TN

End your journey with breakfast at the hotel with fellow travelers. Should you choose to stay, there’s so much left to see so take your time to see as much as you can. Knoxville, a city that combines Southern charm with a vibrant arts scene, offers visitors a unique blend of historic architecture and modern innovation. From its lively downtown to scenic river views, Knoxville is the perfect place to end your national park adventure.